1,520 Alzheimers Headlines
Patricio Reyes M.D., F.A.N.N.
Director, Traumatic Brain Injury, Alzheimer's Disease & Cognitive Disorders Clinics; Phoenix, AZ; Chief Medical Officer, Retired NFL Players Association

Barrow Neurological Institute
St. Joseph's Hospital and Medical Center
"2 NEW THERAPIES FOR ALZHEIMER'S"
Produced by MD Health Channel
Executive Editor.....Anne-Merete Robbs
CEO..............Stan Swartz

Dr. Reyes and his team are constantly working on new medicines and new solutions...You will receive news alerts...information on new trials as Dr Reyes announces them!
"2 NEW THERAPIES FOR ALZHEIMER'S"
Patricio Reyes M.D., F.A.N.N.
Director, Traumatic Brain Injury, Alzheimer's Disease & Cognitive Disorders Clinics; Phoenix, AZ; Chief Medical Officer, Retired NFL Players Association

St. Joseph's Hospital and Medical Center



DO YOU HAVE ALZHEIMERS?
 
"HELP DR. REYES... IN HIS BATTLE TO FIND A CURE...
.HE NEEDS YOUR HELP:
YOU CAN HELP WIN THE BATTLE FOR A CURE BY JOINING A TRIAL!!"....

Stan Swartz, CEO,
The MD Health Channel



"You'll receive all medication and study based procedures at
no charge

if you qualify for one of the many trials being conducted at Barrow Neurological Institute."
 

"Dr. Reyes Changed My Life"

- John Swartz
92 Years Old
Attorney at Law
"Dr.Reyes Changed My Life "
1:18
"At 92...I had lost my will to live"
5:48
Tips on Aging
2:29
"Dr. Reyes gave me customized health care"
2:09

Patricio Reyes M.D.
Director, Traumatic Brain Injury, Alzheimer's Disease & Cognitive Disorders Clinics; Phoenix, AZ; Chief Medical Officer, Retired NFL Players Association

Barrow Neurological Institute

St. Joseph's Hospital and Medical Center
"PRESERVING BRAIN FUNCTIONS "
Runtime: 50:22
Runtime: 50:22
"2 NEW THERAPIES FOR ALZHEIMER'S"
Runtime: 10:27
Runtime: 10:27
ALZHEIMER'S AWARENESS PROGRAMS
Runtime: 5:00
Runtime: 5:00
BIOMEDICAL RESEARCH IN ALZHEIMER'S DISEASE
PDF Document 850 kb

Download Free

4 TALES OF NEUROSURGERY &
A PIANO CONCERT BY DR. SPETZLER...
Plus 2 books written by Survivors for Survivors!
Robert F. Spetzler M.D.
Director, Barrow Neurological Institute

J.N. Harber Chairman of Neurological Surgery

Professor Section of Neurosurgery
University of Arizona
TALES OF NEUROSURGERY:
A pregnant mother..a baby..faith of a husband.. .plus... Cardiac Standstill: cooling the patient to 15 degrees Centigrade!
Lou Grubb Anurism
The young Heros - kids who are confronted with significant medical problems!
2 Patients...confronted with enormous decisions before their surgery...wrote these books to help others!
A 1 MINUTE PIANO CONCERT BY DR. SPETZLER

Michele M. Grigaitis MS, NP
Alzheimer's Disease and Cognitive Disorders Clinic

Barrow Neurological Clinics
COPING WITH DEMENTIA
 
Free Windows Media Player Click

Links
Barrow Neurological Institute

Archives
October 2006  
November 2006  
December 2006  
January 2007  
February 2007  
March 2007  
May 2007  
June 2007  
November 2007  
December 2007  
April 2008  
July 2008  
August 2008  
September 2008  
October 2008  
November 2008  
December 2008  
January 2009  
February 2009  
March 2009  
April 2009  
May 2009  
February 2010  
March 2013  
May 2013  
November 2013  
January 2014  
February 2014  
March 2014  
April 2014  
May 2014  
June 2014  
July 2014  
June 2016  
July 2016  
August 2016  
September 2016  
October 2016  
November 2016  
December 2016  
January 2017  
February 2017  
March 2017  
April 2017  
May 2017  
June 2017  
July 2017  
August 2017  
September 2017  
October 2017  
November 2017  
December 2017  
January 2018  
February 2018  
March 2018  
April 2018  
May 2018  
June 2018  
July 2018  
August 2018  
September 2018  

This page is powered by Blogger. Isn't yours?

Thursday, February 16, 2017

 

Another Potential Alzheimer's Disease Treatment Bites the Dust: What's Next?






























And another one bites the dust.

Merck (NYSE: MRK) announced on Tuesday that it was halting a phase 2/3 clinical study of  in treating Alzheimer's disease. This news marked the second major clinical failure in recent months by a big drugmaker for a disease that still has no effective treatment. Eli Lilly (NYSE: LLY) reported disappointing results for solanezumab in treating Alzheimer's disease in November.

Why are these drugs proving to be ineffective? And is a pipeline candidate with a real shot at beating Alzheimer's disease anywhere in sight? 

Image source: Getty Images.

What's not working
Merck's  inhibits the beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). BACE1 is an enzyme that's involved with the development of amyloid beta. Amyloid beta consists of pieces of protein that clump together and build up over time into amyloid plaque in the brain. The goal of BACE inhibitors is to prevent the buildup of this  and thereby slow the progression of Alzheimer's disease.

Verubecestat showed great promise in an early-stage study. Patients with Alzheimer's disease taking a 60 mg dose of the experimental drug experienced  reduction in the levels of beta-amyloid peptides.

Lilly's solanezumab also targeted the buildup of amyloid  but through a different mechanism. The humanized monoclonal antibody binds with soluble forms  the peptide that are thought to interfere with cognitive function.

But while  reduced amyloid beta, Merck's external data-monitoring committee stated that the experimental drug had "virtually no chance of finding a positive clinical effect" in improving cognition. Lilly's drug had already failed to improve cognition in two previous late-stage studies.

However, the drugmaker initially saw some potential for solanezumab in reducing cognitive decline in patients with a mild form of Alzheimer's disease. Lilly moved forward with another late-stage study, which also flopped.

More attempts
Although Lilly has thrown in the towel for solanezumab, Merck is continuing to evaluate  in a late-stage study for treating Alzheimer's patients with early symptoms of the disease. Lilly and AstraZeneca are partnering on their own BACE inhibitor, which is currently in a late-stage trial.

Roche (NASDAQOTH: RHHBY) has also run into dead ends in the past in treating Alzheimer's disease. Gantenerumab disappointed in a previous phase 3 study targeting the indication. However, Roche thought the experimental drug might have a better chance of success given in higher doses. The company has two late-stage studies currently in progress, one for gantenerumab plus another for crenezumab.

Biogen (NASDAQ: BIIB) claims one of the most promising Alzheimer's disease candidates right now. The biotech announced encouraging results from an  study of aducanumab in 2016. These results showed  in amyloid plaque, and more importantly, the rate of clinical decline in patients. Aducanumab is now in a late-stage study.


Advertisement (1 of 1): 0:05
Other theories
Note that all of the drugs mentioned thus far target reduction of amyloid beta. There are other thoughts, however, about how to treat Alzheimer's disease. A major alternative theory involves preventing  of tau proteins. Like amyloid beta, tau protein deposits have been found in the brain cells of Alzheimer's disease patients.

A couple of companies are pursuing the  theory. Slovakian biotech AXON Neuroscience has a phase 2 study of its AADvac1 tau vaccine in progress. AC Immune is working with Johnson & Johnson on tau vaccine ACI-35 and with Roche on an anti-tau antibody. Both experimental therapies are in early-stage testing.

Story Source: The above story is based on materials provided by BILLINGSGAZETTE
Note: Materials may be edited for content and length