An image of the human brain. (photo credit:REUTERS)

“Is there really a magic bullet, one treatment that covers all aspects of Alzheimer’s? Not likely.”

Amyloid beta peptides and the plaque they sprout in diseased brains have been blamed for the last two decades on Alzheimer’s disease. However, progress in treating – not to mention curing – the debilitating, neurodegenerative disease has been extremely slow.

A Tel Aviv University study published recently in the Journal of Alzheimer’s Disease suggests a new target for Alzheimer’s research – the APOE gene. This gene, like Dr. Jekyll and Mr. Hyde, has two faces – a healthy form called APOE3 and a disease-related pathological form called APOE4. Researchers have developed a novel mechanism and approach with which to convert the “bad” APOE4 to the “good” APOE3.

Michaelson and other groups found in past research that the bad APOE4 and the good APOE3 differed in their interactions with lipid cargo. The good APOE3, for example, is associated with substantially more lipids than APOE4.

The researchers devised an experimental approach to measure the “bad” features of APOE4, utilizing genetically manipulated mice expressing either good or bad forms of APOE. Mice with APOE4 exhibited impaired learning and memory, as well as damaged brain synapses and an accumulation of phosphorylated tau and a-beta molecules — two pathological hallmarks of Alzheimer’s.

“Once this model was established and the pathological effects of APOE4 could be reproduced in mice, we could test therapeutic approaches and tackle APOE4 itself,” Michaelson said. “Because we know that APOE4 carries fewer lipids, we looked at the means of counteracting the lipidation deficiency.

“We focused on an enzymatic machinery called ABCA1 that loads lipid cargo onto APOE4. We found that the impaired lipidation of APOE4 could be successfully reversed by activating ABCA1. Most importantly, we discovered that this increased lipidation of APOE4 reversed the behavioral impairments and brain damage seen in non-treated APOE4 mice.”

The team found in the course of administering treatment that mice, which prior to the treatment exhibited disoriented behavior and seemed “lost,” were able following treatment to locate a submerged island in the middle of an artificial pond. Mice had forgotten familiar objects – like cola bottles – suddenly exhibited sharp object recognition.

“Is there really a magic bullet, one treatment that covers all aspects of Alzheimer’s? Not likely,” said Michaelson.

Story Source: The above story is based on materials provided by THEJERUSALEMREPORT