1,520 Alzheimers Headlines
Patricio Reyes M.D., F.A.N.N.
Director, Traumatic Brain Injury, Alzheimer's Disease & Cognitive Disorders Clinics; Phoenix, AZ; Chief Medical Officer, Retired NFL Players Association

Barrow Neurological Institute
St. Joseph's Hospital and Medical Center
"2 NEW THERAPIES FOR ALZHEIMER'S"
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Dr. Reyes and his team are constantly working on new medicines and new solutions...You will receive news alerts...information on new trials as Dr Reyes announces them!
"2 NEW THERAPIES FOR ALZHEIMER'S"
Patricio Reyes M.D., F.A.N.N.
Director, Traumatic Brain Injury, Alzheimer's Disease & Cognitive Disorders Clinics; Phoenix, AZ; Chief Medical Officer, Retired NFL Players Association

St. Joseph's Hospital and Medical Center



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"Dr.Reyes Changed My Life "
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Patricio Reyes M.D.
Director, Traumatic Brain Injury, Alzheimer's Disease & Cognitive Disorders Clinics; Phoenix, AZ; Chief Medical Officer, Retired NFL Players Association

Barrow Neurological Institute

St. Joseph's Hospital and Medical Center
"PRESERVING BRAIN FUNCTIONS "
Runtime: 50:22
Runtime: 50:22
"2 NEW THERAPIES FOR ALZHEIMER'S"
Runtime: 10:27
Runtime: 10:27
ALZHEIMER'S AWARENESS PROGRAMS
Runtime: 5:00
Runtime: 5:00
BIOMEDICAL RESEARCH IN ALZHEIMER'S DISEASE
PDF Document 850 kb

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4 TALES OF NEUROSURGERY &
A PIANO CONCERT BY DR. SPETZLER...
Plus 2 books written by Survivors for Survivors!
Robert F. Spetzler M.D.
Director, Barrow Neurological Institute

J.N. Harber Chairman of Neurological Surgery

Professor Section of Neurosurgery
University of Arizona
TALES OF NEUROSURGERY:
A pregnant mother..a baby..faith of a husband.. .plus... Cardiac Standstill: cooling the patient to 15 degrees Centigrade!
Lou Grubb Anurism
The young Heros - kids who are confronted with significant medical problems!
2 Patients...confronted with enormous decisions before their surgery...wrote these books to help others!
A 1 MINUTE PIANO CONCERT BY DR. SPETZLER

Michele M. Grigaitis MS, NP
Alzheimer's Disease and Cognitive Disorders Clinic

Barrow Neurological Clinics
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Tuesday, October 10, 2006

 
New drug may help Alzheimer patient : valproate:.../CLICK FOR LINK TO STUDY
Researchers are testing an old drug to delay the onset of aggression in people with Alzheimer’s disease. The drug, valproate, is already FDA-approved for epilepsy, migraine headaches and bipolar disorder. The study, led by researchers at the University of Rochester (National Institutes of Aging sponsored study), is looking at whether the drug delays the onset the agitation common with Alzheimer’s disease. Previous studies have shown valproate does provide a beneficial effect for agitation in some, though not all, patients.

PROMISING FINDINGS:

Researchers are excited by more than valproate’s effects on agitation. They say the drug may actually help protect the brain. Dr. Ismail explains, “[Valproate] can actually modify what is happening at the cellular level. We are hoping that it actually protects the cell from being stressed out or being damaged. If those cells could be preserved longer, that would translate into meaningful outcomes.”

The study is the first of its kind to study a drug that could block one of the hallmarks of AD -- “tangles.” Tangles are abnormal brain tissue structures formed by abnormal processing of a protein called tau. In healthy people, tau is critical for intracellular functioning and structure. In patients with Alzheimer’s disease, stringy clusters of tau and phosphate molecules form. This leads to an impairment of the cells' ability to transport material within the cell. When the cell does not function the way it should it cannot communicate efficiently with other cells. Eventually, this process leads to cell death. Dr. Ismail says, “This is just one aspect of what we think is valproate’s potential to work. More recently, there has been evidence that it works [another way].” He says the drug also probably works on the clearance and production of amyloid. Amyloid plaques are found outside the neurons, and neurofibrillary plaques are found inside the neurons. Neurons are the nerve cells within the brain. These plaques are found in large amounts in people with Alzheimer's disease.

Dr. Ismail is hopeful that valproate will offer new hope. “It’s very exciting. Scientifically, it is novel. The theory behind it is very impressive, and the good thing about it is that the evidence is growing.”